Aim To evaluate the effect of growth differentiation factor-15 (GDF-15) in predicting no-reflow in patients with acute myocardial infraction (AMI) undergoing percutaneous coronary intervention (PCI). Methods Totally 243 consecutive patients with AMI were enrolled and serum GDF-15 levels were measured within 24 hours. All patients were divided into two groups according to the occurrence of no-reflow during PCI. Results There were 44 patients in no-reflow group (average age was 67.00±13.04 ) and 199 patients in normal-reflow group (average age was 65.54±12.98). The serum GDF-15 levels increased in no-reflow group (1073.43±364.38 ng/L vs 714.10±340.98 ng/L, P<0.001). The area under the receiver operating characteristic curves (AUC) was 0.829 (95%CI:0.766～0.892). Logistic regression showed that GDF-15 (OR:1.3,5% CI:1.001～1.004, P＜0.001) and female (OR:2.6,5%CI:1.358～6.610, P=0.007) were independent risk factors for no-reflow during PCI in AMI patients. Conclusion GDF-15 and female were independent risk factors for no-reflow during PCI in AMI patients.