Aortic dissection (AD) is a high-risk vascular disease, and more and more scholars pay attention to the research of its pathogenesis, prevention and treatment. At present, the animal models of AD can be divided into in vivo models and in vitro models. In vivo models include mechanical modeling, chemical induced modeling and genetic engineering modeling. In vitro model is to simulate the formation of AD in vitro. In this paper, the research progress of AD model is reviewed.