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慢性肾脏病患者成纤维细胞生长因子23、Klotho蛋白与颈动脉内膜中膜厚度的相关性
作者:
作者单位:

(1.青岛大学附属海慈医院 肾病科,山东省青岛市 266001;2.青岛大学附属海慈医院干部保健科,山东省青岛市 266001;3.青岛大学附属海慈医院科研科,山东省青岛市 266001)

作者简介:

陈金艳,博士,主治医师,研究方向为肾脏疾病诊治,E-mail为hhl_qd@126.com。

基金项目:

青岛市中医药科研计划(2017-zyx015)


Relationship between fibroblast growth factor 23, Klotho protein and carotid intima-media thickness in patients with chronic kidney disease
Author:
Affiliation:

1.Department of Nephrology, ;2.Department of Cadre Health Care, ;3.Department of Scientific Research, the Affiliated Haici Hospital, Qingdao University, Qingdao, Shandong 266001, China)

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    摘要:

    目的 探讨慢性肾脏病(CKD)2～5期非透析患者血清成纤维细胞生长因子23(FGF-23)、Klotho蛋白水平与颈动脉粥样硬化程度的关系。 方法 对126例CKD2～5期患者用彩色超声测定其颈动脉内膜中膜厚度(CIMT),根据CIMT分为CIMT增厚组及CIMT正常组。酶联免疫吸附法测定血清FGF-23、Klotho蛋白水平,收集患者一般资料及临床生化指标。对两组相关指标进行比较,分析FGF-23、Klotho蛋白与颈动脉硬化的相关性。采用非条件Logistic回归分析进行CIMT影响因素的多因素分析。 结果 CIMT增厚组血清FGF-23水平明显高于CIMT正常组(435.39±221.20比360.22±194.26,P＜0.05),Klotho蛋白水平明显低于CIMT正常组(446.54±132.49比499.36±121.38,P＜0.05)。多因素逐步回归分析显示,Klotho蛋白是CKD患者CIMT增厚的独立保护性因素(OR＝1.086,P＜0.05),而年龄增长、FGF-23是CKD患者CIMT增厚的独立危险因素(OR＝1.075,P＜0.05；OR＝1.238,P＜0.05)。 结论 CKD2～5期非透析患者CIMT增厚与FGF-23、Klotho蛋白有关,FGF-23、Klotho蛋白在颈动脉硬化的发生发展中起重要作用。

    Abstract:

    Aim To investigate the relationship between serum levels of fibroblast growth factor 23 (FGF-23), Klotho protein and carotid atherosclerosis in non-dialysis patients with chronic kidney disease (CKD) 2-5 stage. Methods 126 CKD 2-5 stage patients were involved in the study. Carotid intima-media thickness (CIMT) was measured by color Doppler ultrasonography. The patients were divided into CIMT thickening group and CIMT normal group according to CIMT. Serum levels of FGF-23 and Klotho protein were determined by enzyme-linked immunosorbent assay, and the general data and clinical biochemical indexes were collected. The relative indexes of the two groups were compared, and the correlation between FGF-23, Klotho protein and carotid atherosclerosis was analyzed. Unconditional Logistic regression analysis was used for multivariate analysis of CIMT influencing factors. Results The serum FGF-23 level in CIMT thickening group was significantly higher than that in CIMT normal group (435.39±221.20 vs 360.22±194.26, P＜0.05), and the level of Klotho protein was significantly lower than that in CIMT normal group (446.54±132.49 vs 499.36±121.38, P＜0.05). Multivariate stepwise regression analysis showed that Klotho protein was an independent protective factor for CIMT thickening in patients with CKD (OR＝1.086, P＜0.05), while age increase and FGF-23 were independent risk factors for CIMT thickening in patients with CKD (OR＝1.075, P＜0.05; OR＝1.238, P＜0.05). Conclusion CIMT thickening is related to FGF-23 and Klotho proteins in non-dialysis patients with CKD 2-5 stage. FGF-23 and Klotho protein play an important role in the occurrence and development of carotid atherosclerosis.

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引用本文

陈金艳,胡勇,孙红,姜婷,刘先英.慢性肾脏病患者成纤维细胞生长因子23、Klotho蛋白与颈动脉内膜中膜厚度的相关性[J].中国动脉硬化杂志,2017,25(9):919~922.

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  • 收稿日期:2016-07-05
  • 最后修改日期:2017-05-02
  • 在线发布日期: 2017-09-29

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