A soluble glycoprotein, termed osteoprotegerin, is a novel member of the tumor necrosis factor receptor superfamily. Recent studies have shown that osteoprotegerin is not only involved in bone metabolism, but also closely related to energy metabolism in vivo, glycolipid metabolism. And it is closely related to atherosclerosis and glycolipid metabolism disorders, cardiovascular and microvascular diseases. It is not clear that the mechanism is involved in the occurrence and progression of atherosclerosis by regulating glucose and lipid metabolism, endothelial function, inhibiting vascular calcification, inhibiting inflammation, inhibiting apoptosis and so on.