Cardiovascular diseases, such as myocardial infarction, chronic heart failure, are the main causes of human death. It is clear that lipid metabolic dysfunction, diabetes and so on are important risk factors for the occurrence and development of cardiovascular diseases. Changes in myocardial structure, Ca²＋ signaling, cellular metabolism, oxidative stress, activation of renin-angiotensin system and mitochondrial dysfunction are associated with the development of cardiovascular diseases. Since β₃-adrenoceptor (β₃-AR) has been cloned in 1989, the researchers have found that β₃-AR is associated with cardiovascular diseases. β₃-AR stimulation can regulate lipid metabolism, improve cardiac function and remodeling, therefore, perhaps prevent and treat cardiovascular diseases.