Aim To explore the effects of cardiac exercise rehabilitation on cardiopulmonary function and quality of life in patients with coronary heart disease after percutaneous coronary intervention(PCI). Methods 110 patients with coronary heart disease who were diagnosed and had undergone PCI were randomly divided into the rehabilitation group and the control group, according to the order of treatment and personal wishes, 55 cases in each group. General data of patients, cardiopulmonary exercise test after 6 months of exercise, cardiac ultrasound related indicators and Seattle angina scale (SAQ) were collected, and statistical analysis was performed to assess the effects of cardiac exercise rehabilitation on cardiopulmonary function and quality of life in patients with coronary heart disease after PCI. Results After 6 months exercise rehabilitation treatment, the anaerobic threshold(AT), maximal oxygen uptake(VO₂ max), oxygen pulse(O₂ pulse), maximal exercise time, left ventricular ejection fraction(LVEF) and SAQ score in the rehabilitation group were significantly higher than before intervention and control group (P<0.05). Conclusions Cardiac exercise rehabilitation therapy can improve cardiopulmonary function, exercise endurance and quality of life in patients with coronary heart disease after percutaneous coronary intervention. It is an important part of secondary prevention in patients with coronary artery disease after percutaneous coronary intervention.