Cardiovascular disease (CVD) is a serious threat to human health. It is an urgent problem for clinicians to early detect and prevent the occurrence of cardiovascular events. Atherogenic index of plasma (AIP) is an independent predictor of CVD proposed in recent years. It is derived from the logarithm conversion of the ratio of triglyceride (TG) to high density lipoprotein cholesterol (HDLC), i.e., log[TG/HDLC]. Compared with the previous single index, AIP can more comprehensively reflect the level of lipid metabolism, which is of great significance for clinical diagnosis and treatment monitoring of diseases. This article reviews the application of AIP in CVD.