With the development of multi-omics detection technology, researchers have more understanding of the metabolic changes in the process of cardiac remodeling. On the one hand, the process of cardiac remodeling involves not only the metabolism of fatty acids, glucose and amino acids, but more and more new metabolites are concerned; on the other hand, highly attention has been paid for the interaction between different organs and the heart. This review plans to explain the interaction between cardiac remodeling and metabolism.