Vascular calcification (VC) increases the incidence of cardiovascular events in patients with chronic kidney disease, hypertension and diabetes mellitus. However, up to now, the molecular mechanism leading to VC has not been fully elucidated, and there is a lack of effective treatment methods, so it is necessary to find new therapeutic targets.With the development of molecular biological analysis technology, non-coding RNA has become an important research hotspot. It has been reported that non-coding RNA can regulate the expressions of osteogenic gene or osteogenic inhibition gene, or regulate autophagy and aging process to regulate VC under the stimulation of VC promoting factors. This review mainly summarizes the research progress of non-coding RNA (microRNA, long non-coding RNA and circular RNA) in VC.