Aim To investigate the therapeutic effect of Danshen Chuanxiongqin injection combined with metoprolol in the treatment of acute coronary syndrome (ACS) and its improvement effect on blood lipid and cardiac function.Methods 124 patients with ACS admitted to Nanyang Central Hospital were selected from January 2016 to January 2019, and according to the random number table method, the patients were divided into two groups:monotherapy group and combined group, 62 cases in each group. The monotherapy group was treated with metoprolol, while the combined group was treated with Danshen Chuanxiongqin injection and metoprolol. The levels of blood lipids were measured by enzyme colorimetry, including low density lipoprotein cholesterol (LDLC), high density lipoprotein cholesterol (HDLC), triglyceride (TG) and total cholesterol (TC). Echocardiography was used to detect cardiac function indexes:left ventricular end-systolic volume (LVESV), left ventricular end-diastolic volume (LVEDV), left ventricular ejection fraction (LVEF). The level of plasma cardiac troponin I (cTnI) was detected by chemiluminescence. Results The total effective rate of combined group and monotherapy group was 98.39% and 87.10%, respectively, and the difference between the two groups was statistically significant (χ²＝5.871, P＝0.015). After treatment, the levels of LDLC, TG and TC in the two groups were significantly lower than those before treatment, and HDLC was significantly higher than that before treatment (P＜0.05); the levels of LDLC, TG and TC in the combined group were lower than those in the monotherapy group, and HDLC was higher than that in the monotherapy group (P＜0.05). After treatment, LVESV and LVEDV in the two groups were significantly smaller than those before treatment, LVEF was significantly higher than that before treatment, cTnI was significantly lower than that before treatment (P＜0.05); LVESV and LVEDV in the combined group were much smaller than those in the monotherapy group, LVEF was much higher than that in the monotherapy group, cTnI was much lower than that in the monotherapy group (P＜0.05). Conclusion Danshen Chuanxiongqin injection combined with metoprolol has a satisfactory therapeutic effect on ACS patients, which is beneficial to the improvement of blood lipid level and cardiac function, and is worthy of clinical application.