Aim To explore screening value of coronary calcification score combined with triglyceride/high density lipoprotein cholesterol (TG/HDLC) value for cardiovascular events in patients undergoing maintenance hemodialysis (MHD). Methods A total of 110 patients who underwent MHD were enrolled. They were divided into cardiovascular lesion group (n=40) and cardiovascular non-lesion group (n=70) according to presence or absence of cardiovascular events. The coronary calcification degree was scored by multi-slice spiral CT. The contents of serum TG and HDLC were measured. TG/HDLC value was calculated. The receiver operating characteristic curves (ROC curve) were applied to analyze screening value of coronary calcification score combined with TG/HDLC value for cardiovascular events in patients undergoing MHD. Results The body mass index (BMI), TG/HDLC and coronary calcification score in cardiovascular lesion group were significantly higher than those in cardiovascular non-lesion group, while HDLC level was significantly lower than that in cardiovascular non-lesion group (P＜0.05). TG/HDLC and coronary calcification score were independent risk factors for cardiovascular disease in patients undergoing MHD. The diagnostic efficiency of the combination detection was the highest, with the area under the curve (AUC) of 0.925 and 95%CI of 0.869～0.981, which were significantly better than those of single detection. Conclusion Coronary calcification score and TG/HDLC value are independent risk factors for cardiovascular disease in patients undergoing MHD, which can help screen out patients with cardiovascular disease risk from patients undergoing MHD.