Angiogenesis is a process in which existing blood vessels created new vessels under various vascular growth factors control. Pathological angiogenesis is not only regulated by vascular endothelial growth factor (VEGF) but also related to other factors. For instance, inflammatory factors, adhesion molecules, matrix metalloproteinases. Pathological angiogenesis for tumor cells provides the blood supply and nutrients and can help the tumor cells move to distal tissues and organs. Endoplasmic reticulum stress (ERS) is a reaction that intracellular environment change. A slight endoplasmic reticulum stress response may guide the correct protein folding, recover partitions inside the steady-state environment. However, persistent or severe stress leads to a series of diseases. Endoplasmic reticulum stress induces angiogenesis mainly through the activation of three endoplasmic reticulum effectors:X-box binding protein 1, activating transcription factor 4 and splintered activating transcription factor 6. These three effectors can act on downstream pro-angiogenic factors (such as VEGF, IL-8, IL-6, etc.) to promote angiogenesis. Pathologic angiogenesis-related diseases mainly include tumor, atherosclerosis, rheumatoid arthritis, diabetes, etc. This article summarizes the papers concerned with the pathogenic mechanism of endoplasmic reticulum stress and pathological angiogenesis.