Atherosclerosis is a common systemic vascular disease, and it is also the pathological basis of a variety of acute cardiovascular diseases. Acute cardiovascular disease has a high mortality rate, which seriously endangers people's life and health. In recent years, more and more studies have shown that the RhoA/ROCK signaling pathway is closely related to atherosclerosis. Inhibition of RhoA/ROCK signaling pathway can delay or inhibit the formation and pathological changes of atherosclerosis by stabilizing vascular endothelial function, inhibiting the proliferation and migration of vascular smooth muscle cells, inhibiting vascular calcification, regulating inflammatory cell aggregation, and inhibiting platelet proliferation and deformation.