Cardiovascular diseases, as a major threat to human health,are attracting more and more attention. Although the treatment system for cardiovascular diseases has been preliminarily completed, there are still residual risks after controlling related risk factors. It is still difficult and the mortality remains stubbornly high. Intestinal flora is an important part of human physiological and metabolic homeostasis, especially its metabolite level may be closely related to some diseases. Intestinal flora metabolites are regarded as a new break-through in the prevention and treatment of cardiovascular diseases. The purpose of the current review is to explore the relationship between intestinal flora metabolites and common cardiovascular diseases such as coronary heart disease, heart failure, hypertension and arrhythmia,hoping to provide new ideas for the prevention and treatment of cardiovascular diseases.