Aim To study the correlation between galectin-3 (Gal-3) and the severity of coronary artery disease by Meta-analysis. Methods Through searching the related study on Gal-3 and coronary artery lesions in PubMed, Cochrane Library, Embase, CNKI, Wanfang and VIP internet databases, two researchers screened the literature and extracted data respectively. WPS software was used to transform the correlation coefficient, Fisher's Z transformation and inverse transformation. Revman 5.3 software was used to perform Meta analysis, heterogeneity test and sensitivity analysis. Stata 14.0 software was used to perform publication bias analysis. Results 14 studies involving 1 560 patients with coronary heart disease were included in this study. According to the Meta-analysis results of the correlation between Gal-3 and genisi score, the summary Fisher'Z was 0.79, I² was 12% (P＜0.01), and the summary r was 0.66. Conclusion The concentration of Gal-3 in blood is closely related to the degree of coronary artery stenosis. With the increase of Gal-3 concentration in blood, it may indicate the aggravation of coronary artery stenosis.