Mechanical force signals play an important role in the regulation of some cardiovascular diseases. Mechanical stress can be divided into tensile stress and shear stress. Tensile stress can affect all types of cells in blood vessels, while shear stress mainly affects endothelial cells, which cause changes in intracellular chemical signals through the action of mechanosensors, thereby regulating various life activities. Shear stress can regulate the occurrence of atherosclerosis and coronary heart disease by regulating inflammation-related signaling pathways; Various mechanical stresses can regulate the proliferation of vascular endothelial cells and smooth muscle cells, and induce fibrosis of the extracellular matrix, thereby increasing blood pressure and regulating occurrence of pulmonary arterial hypertension, and regulate the occurrence of cardiac hypertrophy by regulating MAPK, JAK/STAT and other signaling pathways. This review explores the relationship between mechanical force signals and the occurrence and development of some cardiovascular diseases, and expounds the molecular mechanism of mechanical force signals inducing some cardiovascular diseases, thus deepening our understanding of the occurrence and development of some cardiovascular diseases and providing some clues for their treatment.