With the development of population aging and urbanization, the morbidity and mortality of cardiovascular diseases are continuously increasing, posing a serious threat to human life, health and safety. The onset and course of cardiovascular diseases are affected by many factors, and the dysregulation of intestinal flora as one of them has attracted a lot of attention. Intestinal flora is a microflora that exists in the gastrointestinal tract and has a mutually-beneficial symbiosis with the human body. More and more studies have shown that the intestinal flora and cardiovascular diseases interact with each other, and the two are mutually causal, targeted intervention of cardiovascular diseases by regulating intestinal flora can become a new therapeutic idea. Modern studies have found that traditional Chinese medicine (TCM) compounds, TCM monomers and acupuncture can effectively correct the dysregulation of intestinal flora, up-regulate the number of probiotics, restore intestinal barrier function and reduce inflammation. Based on the above studies, this paper summarized the interaction between intestinal flora and its metabolites and cardiovascular diseases, and also summarized the therapeutic effects of some TCM in regulating intestinal flora, restoring the dynamic balance of intestinal flora, treating the heart with intestines and intervening in cardiovascular diseases, in order to provide new ideas and feasible schemes for the prevention and treatment of cardiovascular diseases.