Ferroptosis is defined as an iron-dependent regulated form of cell death driven by lipid peroxidation, which is not only regulated by a variety of cellular metabolic pathways, but it is also related to neurodegenerative diseases, tumors, cardiovascular diseases and so on. Recent studies have found that ferroptosis plays a crucial part in the process of atherosclerosis. This article reviews the role and molecular mechanism of ferroptosis in the pathological processes of atherosclerosis, such as vascular endothelial cell dysfunction, macrophage polarization, foam cell formation, vascular smooth muscle cell proliferation and migration, and summarizes the ferroptosis inhibitors and related targets that may have therapeutic effects on atherosclerosis. The aim is to provide a new therapeutic direction for atherosclerosis from the perspective of ferroptosis.