Atherosclerosis is the pathological basis of a variety of cardiovascular diseases, which are still the leading cause of human death worldwide. Ferroptosis is a kind of iron dependent non-apoptotic cell death mode, which is closely related to various physiological mechanisms. Recent studies have found that ferroptosis in macrophages plays an important role in the occurrence and development of atherosclerosis. Based on the imbalance of iron metabolism in macrophages, this paper reviews the correlation between ferroptosis in macrophages and atherosclerosis in terms of the interaction between ferroptosis in macrophages and lipid peroxidation, inflammation, oxidative stress, etc., in order to provide new ideas for the study of the pathogenesis of atherosclerosis.