Plasma concentrations of apoproteins A and B were investigated in forty—eight patients with coronary heart disease (CHD) and thirty—six health control subjects, in the meantime. serum triglyceride(TG). total Cholesterol (TC), HDL—C were also investgated. The results showed that plasma concentrations of apoA in CHD group were markedly lower than that in control group (p<0.01), apoB/apoA ratioes in CHD were significantly higher that in controls. (p<0.05). Serum concentrations of TG were markedly higher in CHD than that in normal group (p<0.01). No significant differences existed between CHD and normal group in plasma concentrations of apoB and TC. The decrease of plasma apoA level was the best parameter to distinguish CHD from non-CHD.