We reported the effect of L-arginine on lipoprotein, nitric oxide(NO), lipid peroxide (LPO) and superoxide dismutase (SOD) in hypercholesterolaemic rabbit. The results showed that 2% L-arginine fed in company with 2% cholesterol for 90 days and 4%L-argine orally administrated for 90 days after 2%L-arginine and 2% cholesterol could significantly protect the activity NO and SOD, decrease the LPO content. L-Arg/NO may reduce the oxidative modification of LDL of hypercholesterolaemic rabbit.