Aim This work investigated the protective role ofcalcitonin gene-related peptide (CGRP) on balloon de-nuded injury of rat aorta.Methods Per fusion of denuded arterial rings, de-termination of cGMP and endothelin (ET) with re-dioactive analysisResults 2 weeks after denudation, the contents ofplasma and aorta CGRP were increased. ExogenousCGRP (25 μg/kg, iv) could significantly improve therelaxation of denuded aorta to acetyl choline, inducenitric oxide (NO) synthesis (p<0. 01 ), and inhibitthe over proliferation of denuded intima (p<0. 01 ).Couclusion Exogenous CGRP could prevent therestenosis of balloon denided aorta through promtingthe repairment of denuded endothelium, inhibiting theover proliferation of injured intima.