Aim To analyze the lipid profile changes in chronicrenal failure patients.Methods Forty cases of chronic renal failure patients were studied. Triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDLC), low density lipoprotein cholesterol (LDLC).apolipoprotein AI (Apo AI) and apolipoprotein B (ApoB) were assessed.Results The values of TG, Apo B were higher andvalues of HDLC, Apo AI, Apo AI/Apo B were lowerin chronic renal failure patients compared with control group. The values of TC and LDLC, however, were no different from that values in the control group.Conclusion Lipids abnormorlities were present in some chronic renal failure patients.