Aim To investigate the effect of antioxidant Vitamine E and Selenium on the expression of cellular adhesion molecules(CAMs) induced by lipid peroxidation(LPx) in cultured endothelial cells and monocytes(MC) adherence to EC. Methods LPx was initiated withdiamide(DM).Effect of Vitamine E and Selenium on the expression of vascular adhesion molecule-1(VCAM-1) and endothelial leucocyte adhesion molecule-1(ELAM-1) was studied under laser confocal microscope,MC adherence to EC was measured. Results Vitamine E and Selenium could decrese the content of lipid peroxid,reduce VCAM-1 and ELAM-1 expression andMC adherence to EC incubated with DM. Conclusion Antioxidant could inhibite VCAM-1 and ELAM-1expression induced by LPx to reduce Mc adherence to EC and may possiboly prevent the development of athrosclerosis (As) lesion.