Aim To educidate the changes of lipoprotein(a) [Lp(a) ] in cerebrospinal fluid (CSF) and serum in patients with cerebral infarction. Methods The CSF and the serum Lp(a) levels were measured with an enzyme-linked immunosorbent assay (ELISA) in 80 patients with acute cerebral infarction and 40 control subjects. [WT5”HZ]Results [WT5”BZ]Lp(a) levels in the CSF and serum of cerebral infarction patients were significanthy higher than that of the controls (234±29 μg/L vs 211±21 μg/L and 0.299±0.028 g/L vs 0.275±0.025 g/L). Lp(a) concentration in the CSF of cerabral infarction patients and controls is not related to that of serum ( P>0.05 ). Conclusion The CSF and the serum Lp(a) levels in patients with cerebral infarction were significantly higher than those in cortrols.