Aim [WT5”BZ]To invistgate possible associations between lipoprotein(a) [Lp(a)] and the severity ofcoronary artery diseases. [WT5”HZ]Methods [WT5”BZ]Lipids apoprotein and Lp(a) concentrations in 74 patients with chest pain were measured. Of 74 patients who underwent coronary artery angiography with Judking's technique, twenty six patients were normal (control group), the other forty eight were abnormal (the lumen of coronary artery was occluded by 50% or more). The latter was divided into two group saccording to its number of injured vessels. We used ascoring method of coronary artery diseases to reflect the extent of coronary artery narrowing. [WT5”HZ]Results [WT5”BZ]That serum Lp(a) concentrations have a significant difference between normal group and abnormal group. Multiple stepwise regression analyses revealed that Lp(a) is an independent risk factors for coronary artery. In abnormal group, Lp(a) concentrations increase with the severity of coronary artery lesions, there is no statistical difference between the two groups. [WT5”HZ]Conclusions [WT5”BZ]Lp(a) is an independent risk factor for coronary artery disease and, to some degree, has clinical significance in valuing coronary artery diseases.