青年高血压病患者血管内皮依赖性舒张功能的无创伤性评价
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Noninvasive Assessment of Endothelium-Dependent Vasodilation in Young Patients with Hypertension
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    摘要:

    为了评价无其它动脉粥样硬化因素及粥样斑块的青年高血压病患者的血管内皮依赖性舒张功能,用B型超声对45例35岁以下的青年高血压病患者和2 0例健康对照者在反应性充血和舌下含服硝酸甘油后肱动脉内径进行了检测。结果发现,青年高血压病患者前臂加压后肱动脉内径增加的比例明显小于对照组(前者为12 .32 %±4.94% ,后者为16 .6 3%±5 .87% ,P<0 .0 1) ,而在舌下含服硝酸甘油后肱动脉内径的变化两组间无显著性差异(前者为18.94%±6 .5 0 % ,后者为2 1.0 2 %±6 .6 5 % ,P>0 .0 5 )。提示青年高血压病患者虽然没有明显的动脉粥样硬化的证据和其它易患因素,但已经存在显著的血管内皮依赖性舒张功能障碍。

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    Aim To evaluate the endothelial function in young hypertensive patients with no evidence of plaque formation and other risk factors for arterial sclerosis. Methods 45 young hypertensive patients and 20 matched healthy subjects were included in this study. Two-dimensional ultrasonography was used to determine the diameter of the brachial artery during reactive hyperemia caused by endothelium-dependent dilatation and the diameter of the same artery after sublingual glyceryl trinitrate induced by endothelium-independent dilatation. Result Despite the similarity of 2 groups in age, blood lipids and blood glucose levels, the increased percentage of the brachial artery diameter was lower in patients group than in normal control (12.32%±4.94% versus 16.63%±5.87%,P<0.01) during reactive hyperemia. There was, however, no significant difference in response to glyceryl trinitrate between two groups (18.94%±6.50% versus 21.02%±6.65%, P>0.05). Conclusion Endothelial dysfunction is present in young patients with essential hypertension before clinical evidence of atherosclerosis.

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张延斌,黄宗明,吴兰芬,陈清枝.青年高血压病患者血管内皮依赖性舒张功能的无创伤性评价[J].中国动脉硬化杂志,2001,9(4):325~327.

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  • 收稿日期:2000-11-16
  • 最后修改日期:2001-04-24
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