Aim To study the effect of lipid-lowing treatments on prognosis and reducing blood lipid in old people with hyperlipidemia. Methods 95 old people with hyperlipidemia were divided into three groups randomly.All patients received low fat diet. Patients of group 1 were treated with Fluvastatin 20 mg alternation night for two years. Group 2 were treated with Fluvastatin 20 mg every night for three month. No lipid lowing drug was received in group 3(control group). Investigation was followed up for two years. Results Plasma lipids level of the patients in the group 1 (TC 5.7±1.3 mmol/L,LDL 3.2±0.7 mmol/L)and group 2 (TC 5.5±0.9 mmol/L,LDL 3.0±0.7 mmol/L)was significantly lower at the 3rd month than that before treatment (p<0.05,p<0.01). Two years later,the plasma lipid were markedly decreased in group 1(TC 4.9±1.2 mmol/L,LDL 2.7±0.9 mmol/L,p<0.001),however,that of group 2(TC 5.7±1.0 mmol/L、LDL 3.2±0.7 mmol/L)increased again,the difference between these two groups was significant(p<0.05). Plasma lipids level of the patients in the control group (TC 6.5±1.1 mmol/L, LDL3.7±0.8 mmol/L)was the same in two years than that before treatment(p>0.05).Compared with group 2,plasma lipids level of the patients in group 1significantly decreased two years later(p<0.05). The incidence of cardiovascular events of group 1 (9%)was lower than group 3 (56.2%,p<0.01) and group 2 (31.2%,p<0.05). Conclusion It was safe and effective to take low-dose lipid-lowing drug of Fluvastatin for a long time. The incidence of cardiovascular events and coronary heart disease was decreased.