Aim To investigate the apoptotic function of the oxidized LDL and Lp(a) on the endothelia cells and the roles of PPAR during the process. Methods hUVEC were isolated from fresh umbilical cords obtained at normal deliveries. The LDL and Lp(a) were obtained by density-gradient ultracentrifugation and were oxidized through incubation with 15 μmol/L CuSO 4. The apoptosis of endothelia cells was observed with the oxidized lipoproteins at different time points by the measurements of TUNEL and electronical microscope. The changes among the apoptosis,inflammation factors and NF-κB with the pretreatments of gemfibrozil and troglitazone were observed. The activation of PPARα and PPARγ were tested by immunohistology. The secretion of IL-6 was measured with ELISA. The expression of IL-6R, IL-6 and NF-κB were performed by FACS. Results The oxidized LDL and Lp(a) induced the apoptosis of endothelia cells which was accentuated with 6, 12, 18 and 24 h points. Gemfibrozil and troglitazone relieved the function of oxidized lipoproteins through the activation of PPARα and PPARγ respectively accompanying the lower expression of IL-6 and IL-6R. Conclusions Oxidized lipoprotein can induce the apoptosis of endothelia cells with a time-depended style. PPARα and PPARγ may relieve the apoptosis of vascular cells through the inhibition of inflammation factors.