Aim To investigate the changes of transcranial doppler (TCD) in mind-body relaxing therapy (MBRT) of patients with cerebral arteriosclerosis (CAS). Methods 60 CAS patients were randomly divided into mind-body relaxing therapy with routine treatment group (n=30) and routine treatment group (n=30) for the treatment of 8 weeks. The clinical effects were assessed by TCD. Results Compared with before treatment, Vm, Vs, and Vd of base artery (BA) and left middle cerebral artery (LMCA )were significantly increased, RI and PI were significantly decreased in mind-body relaxing therapy with routine treatment group after treatments of 8 weeks (p<0.05 or p<0.01); the significant rate and total effctive rate of TCD frequency spectrum in mind-body relaxing therapy with routine treatment group were higher than routine treatment group (p< 0.05 ). Conclusion The mind-body relaxing therapy can significantly improve the blood flow velocity, reduce the resistance of cerebral blood vessel, and increase therapeutic effect of the patients with CAS. Mind-body relaxing therapy with routine treatment group has better effect in treatment of CAS than routine treatment group.