MENG Xiao-Ping~1,WANG Chao~2,SUN Jian~1,FEI Yu~1,CUI Yan~1,and WANG Li~1
1.Department of Cardiology,Second Hospital,Jilin University,Changchun 130041;2.Department of Cardiology,Central Hospital of Changchun,Changchun 130031,China 在知网中查找 在百度中查找 在本站中查找
Aim To investigate whether serum levels of matrix metalloproteinase(MMP) are associated with the degree of risk in patients with acute coronary syndromes(ACS). Methods Using SDS-PAGE Zymography and Western-Blotting,Serum Pro-MMP-2,MMP-2 were measured in 78 patients ACS,28 with unstable angina(UA) and 50 with acute myocardial infarction(AMI).Control group includes 50 healthy volunteers.51 cases were in stable angina group. Results Serum MMP-2 was significantly increased in both UA(455±51 INT·mm~2)and AMI group(503±45 INT·mm~2)compared with those in control group(236±33 INT·mm~2) and stable angina(224±23 INT·mm~2)(p<0.05,respectively)by Zymography.But there was no difference between UA and AMI group(p<0.05),and there were no difference between each two subgroups of UA(which are defined low-risk,mid-risk and high-risk group) in duration time of ischemia,ECG and CK-MB/cTnI. Conclusions Increased serum level of activity MMP-2 was detected in patients with ACS.Their findings provide an insight into the unstable plaque association with MMP-2.Serum MMP-2 level appears to be a marker of plaque unstable in patient with acute coronary syndrome.