Aim To study the effects of probucol on ATP binding cassette transporter A1(ABCA1) expression induced by oxidized low density lipoprotein(ox-LDL) in THP-1 macrophages.Methods Reverse transcription polymerase chain reaction(RT-PCR) and immunofluorescence were used to detect ABCA1 mRNA and protein expression respectively.Results ABCA1 mRNA levels in THP-1 macrophages increased in time-dependence pattern after cells incubated for 0 h,12 h,24 h and 48 h with 100 mg/L ox-LDL.After pretreation for 4 h with 50 μmol/L probucol,ABCA1 protein expression induced by ox-LDL for 48 h attenuated,with no change of ABCA1 mRNA levels in THP-1 macrophages.Conclusion Probucol downregulated ABCA1 protein expression induced by ox-LDL.