Aim To explore the relationship between plasma level of B-type natriuretic peptide(BNP) and coronary heart disease(CHD) in patients with type 2 diabetes.Methods 126 patients with type 2 diabetes were selected in this study.31 patients without CHD were as the control;clinical phenotypes of CHD were divided into 3 groups:acute myocardial infarction(AMI) group,32 patients;unstable angina pectoris(UAP) group,33 patients;and stable angina pectoris(SAP) group,30 patients.Plasma levels of BNP were detected on admission in 4 groups.Correlation between BNP and cardiac troponin T(cTnT) which was detected at the same time in SAP,UAP and AMI groups were observed.Results Plasma level of BNP were 41.8±7.5 ng/L,165.2±31.4 ng/L,509.5±125.6 ng/L and 24.1±3.7 ng/L in the patients with SAP,UAP,AMI and the control respectively.The level of BNP was significantly higher in AMI than that in other three groups(p<0.001);the level of BNP was significantly higher in UAP than that in SAP or control(p<0.001).BNP level were highly correlated with cTnT in UAP and AMI(r=0.948,p<0.001).Conclusion Plasma levels of BNP are associated with clinical phenotypes of coronary heart disease and it may reflect degree of myocardial necrosis in patients with type 2 diabetes.