南昌地区健康军人颈动脉内膜中膜厚度和粥样斑块形成的危险因素分析
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The Risk Factors of Carotid Intimia-Media Thickness and Atherosclerotic Plaque in Healthy Army People in Nanchang
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    摘要:

    目的了解南昌地区健康军人颈动脉平均内膜中膜厚度及粥样硬化斑块的形成情况并探讨健康军人动脉粥样硬化的危险因素。方法采用随机整群抽样的方法,选择南昌地区30岁以上健康军人,体格检查正常,收缩压<140mmHg,舒张压<90mmHg;入选后行颈动脉高频率B型超声检查,检查粥样硬化斑块的形成情况,测定颈动脉平均内膜中膜厚度。结果入选800人,颈动脉平均内膜中膜厚度随年龄明显增加(P<0.01);随着年龄增加,性别对颈动脉平均内膜中膜厚度的影响存在差异,男性颈动脉平均内膜中膜厚度仅在40~49岁和50~59岁组明显高于女性(P值分别小于0.01和0.05)。224人检出颈动脉斑块,检出率为28.00%,随年龄明显增加(P<0.01);随着年龄增加,性别对斑块发生率的影响也存在差异,男性斑块发生率仅在40~49岁组明显高于女性(P<0.01)。年龄增加、男性和高低密度脂蛋白水平与颈动脉斑块和颈动脉平均内膜中膜厚度增厚均独立相关,而收缩压升高仅与颈动脉平均内膜中膜厚度增厚独立相关;40~49岁组男性低密度脂蛋白和收缩压水平均明显高于同龄女性(P<0.01)。结论增龄、男性以及低密度脂蛋白水平虽然在正常范围内但是值偏高是颈动脉平均内膜中膜厚度增厚和动脉粥样硬化共同的独立危险因素,而收缩压在正常范围内值偏高仅是颈动脉平均内膜中膜厚度增厚的独立危险因素;男性和女性颈动脉颈动脉平均内膜中膜厚度和斑块形成随年龄增加的变化趋势存在明显差异,动脉粥样硬化的性别差异主要存在于40~49岁组。

    Abstract:

    Aim To investigate the situation and risk factors of carotid artery mean intima-media thickness (MIMT) and atherosclerotic plaques in healthy army people in Nanchang. Methods We performed high-resolution carotid arterial ultrasonography and routine blood detection in 800 healthy army people who were more than 30 years old in Nanchang. Results Mean intima-media thickness increased with age(P<0.01). The age-related increase trend of MIMT was different between male and female. There were no significant differences between gender except in 40-49 and 50-59 groups. The plaque formation rate was 28.00%(224/800), increased with age(P<0.01). The age-related increase trend of plaque formation rate was also different between male and female. There were no significant differences between gender except in 40-49 group. MIMT and atherosclerotic plaque were all independently related to age, gender and low density lipoprotein whose level was normal in usual criterion, while systolic blood pressure was independently related to MIMT only. The low density lipoprotein and systolic blood pressure were significantly higher in male than that in female in 40-49 group(P is less than 0.01and 0.05 respectively). Conclusion Age, gender and low density lipoprotein level were independent risk factors of MIMT and plaque formation while systolic blood pressure was only independently related to MIMT; The age-related increase trends of MIMT and plaque formation rate were significantly different between male and female. Gender difference could mostly be seen in 40-49 group.

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刘秀娟,辛绍南,肖秋金,王志,黄国明,丁仲如,徐劲松.南昌地区健康军人颈动脉内膜中膜厚度和粥样斑块形成的危险因素分析[J].中国动脉硬化杂志,2008,16(5):403~405.

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  • 收稿日期:2007-11-19
  • 最后修改日期:2008-03-15
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