Aim To investigate the influences of probucol combined with atorvastatin and solo atorvastatin on success rate of lipid and prognosis in acute coronary syndrome(ACS) patients at 1 month. Methods Ninety ACS patients were assigned to solo atorvastatin group(20 mg/d atorvastatin for 1 month,n=49) or therapeutic alliance group(20 mg/d atorvastain and 1.0 g/d probucol for 1 month n=41) in a randomized block,controlled study.Serum levels of blood lipids were detected before and aftert teatment.Then prognosis was compared in the two groups. Results The success rate of blood lipids of therapeutic alliance group was higher than solo atorvastatin group,and the prognosis was insignificantly between the two groups. Conclusion Both atorvastatin and probucol may cut down blood lipids in the ACS patients,and atorvastatin combined with probucol can elevate the success rate of blood lipids.