Aim To investigate the association between lipoprotein-associated phospholipase A2(Lp-PLA2) R92H single nucleotide polymorphisms (SNP) and susceptibility to coronary heart disease (CHD) and the degree of coronary artery stenosis. Methods 261 CHD patients and 263 normal controls were genotyped by using single-labeled probe technique. Results The frequencies of the RH genotypes and H allele were significantly higher in CHD patients than normal controls (P<0.05 and P<0.01). Compared with RR genotype, the relative risk for CHD in people with RH genotypes was 1.77 (P<0.01). The relative risk for CHD in people with H allele was 1.619 higher than R allele (P<0.01). Binamy logistic regression analysis showed that polymorphism of R92H was an independent risk factor for CHD. There was a significant increase of total cholesterol (TC) and low density lipoprotein cholesterol (LDLC) in the RH+HH genotype of CHD patients, while high density lipoprotein cholesterol (HDLC) was lower (all P<0.05). The ratio of multiple vessel diseases was significantly increased in the RH+HH genotype of CHD patients (P<0.05). Conclusions The polymorphism of R92H of Lp-PLA2 gene could be associated with risk of CHD in Han Chinese, persons with RH or HH genotypes take higher risk of suffering from CHD.