Aim To observe effect of simvastatin on blood lipid and inflammation target in patients with unstable angina pectoris(UAP). Method Ninety-eight patients with UAP were randomly assigned into control group (n=32) treated without lipid-lowering drugs,20 mg (n=34) and 40 mg (n=32) simvastatin groups administrated simvastatin 20 mg/d and 40 mg/d respectively for 15 days. Blood levels of high sensitive C reactive protein (hs-CRP),nitric oxide (NO),alanine aminotransferase (ALT),creatine kinase (CK) and lipid were all detected before and after the treatment. Results On the 15th day of the trentment,the levels of hs-CRP and lipid were all reduced,especially in 40 mg/d simvastatin group. While the levels of ALT were elevated markedly in 20 mg/d and 40 mg/d simvastatin groups,but the levels of ALT did not exceed the three times of the normal levels,the levels of NO and CK were not changed. Conclusion Treatment with high dose of simvastatin for 15 days in patients with UAP could reduce inflammation and lower blood lipid safely.