Aim To investigate the effect of Maixinkang on peroxisome proliferators-activated receptor γ (PPARγ) and ATP-binding cassette transporter A1 (ABCA1) in vascular smooth muscle cells (VSMCs) derived foam cells,to approach Maixinkang possible regulation mechanism for artherosclerosis (As) foam cells.Methods The cultured VSMCs were loaded with oxidized low density lipoprotein (ox-LDL) and intervened by Maixinkang and Rosiglitazone.The expressions of PPARγ and ABCA1 mRNA were detected with hybridization in situ.Results Maixinkang and Rosiglitazone could raise PPARγ and ABCA1 mRNA,which were significant different to that in the isotonic Na chloride group and the blank group.Moreover,Maixinkang had difference with Rosiglitazone.Conclusions Maixinkang have effect of exciting PPARγ (P<0.01),it is surpass to Rosiglitazone (P<0.01).The molecule mechanism of anti-atherosclerosis is related with the channel of regulating PPARγ.As a new and higher specificity PPARγ excitomotory,Maixinkang is anticipated to supply more effective treatments for anti-atherosclerosis and lipid anomal-metabolism.