Aim To investigate the association of the complement factor H(CFH) 1277T>C polymorphism and unstable angina pectoris(UAP).Methods Frequency distribution of the genotypes and alleles of 1277T>C single nucleotide polymorphisms(SNP) of CFH were detected by using polymerase chain reaction and restriction fragment length polymorphism(PCR-RFLP) method in 150 cases with UAP and 146 normal controls of Hunan Han.Results Obvious frequency distribution difference of TT,TC genotypes and T,C alleles in CFH 1277T>C was observed between the UAP and the control groups(P<0.05),and the difference of the frequency of the CFH 1227C allele carriers(TC+CC genotypes) between the two groups was statistically significant(OR was 3.06,95%CI was 1.60~5.86,P<0.01).Conclusion It is suggested that CFH 1277T>C SNP is significantly associated with UAP in Hunan Han population.