Aim To create an animal model for local change of shear stress to analyze the arterial wall response at different patterns of fluid shear stress. Methods 24 mice were equally randomized into three group (1 h group,4 h group and 24 h group) and one normal control group. A stenosis was set up with a cast attached to the wall of the abdominal aorta to change flow condition in test group. The parameters of hemodynamics and the internal diameter of blood vessel were measured by color Doppler flow imaging. The wall shear stress was calculated by Poiseiulle hydrodynamics formula (τm=η×4×Vm/D). Pathological examination and immunohistochemistry were performed to observe the arterial morphological changes and the endothelial P-selectin expression. The intimal-media thickness and adventitia thickness of the aorta were measured and endothelial P-selectin expression intensity was analyzed qualitatively. Results Regions of low shear stress and oscillatory shear stress were created upstream and downstream of the cast respectively. Vascular remodeling and P-selectin expression in the upstream arterial wall were much more severe than those in the downstream in all observed time-points (P><0.05). Conclusion Vascular remodeling and endothelial P-selectin expression could happen in a relative short time when it exposed under low shear stress,meanwhile the variant patterns of fluid shear stress may play different roles in the pathological process of artery.