Aim To investigate the correlations of atherogenic index of plasma with serum lipids of hyperlipidaemia patients and their thrombotic risk factors.Methods Serum lipids and homocysteine,uric acid,6-Keto-PGF1,TXB₂,FⅦ and other biochemical parameters were detected by standard methods in 100 cases of hyperlipidaemia and 109 controls.The atherogenic index of plasma(AIP)was calculated,and the correlation of AIP,UA,Hcy with other thromboplastic risk factors were analyzed by multiple linear regression respectively.Results Compared to controls,the levels of TC,TG,BMI,AIP,GLU,LDLC,FⅦ,PGI2 and non-HDLC were significantly increased(P><0.01),and the levels of TXB₂ and TXB₂/PGI2 were decreased(P><0.01)in the hyperlipidaemia.The index of AIP was significantly and positively correlated with BMI,DBP,GLU,TG,UA,non-HDLC,SBP,FⅦ and Hcy and negatively correlated with HDLC(P><0.05).Serum homocysteine was significantly and positively correlated with age,SBP,DBP,UA and negatively correlated with HDLC(P><0.01).The level of UA was significantly and positively correlated with TG,BMI,TXB₂(P><0.05 or P><0.01)and negatively correlated with HDLC(P><0.01).BMI was positively correlated with TG,DBP,UA(P><0.01)and negatively correlated with HDLC(P><0.01).Conclusion The levels of AIP,PGI2,non-HDLC and FⅦ were significantly increased in hyperlipidaemic patients compared to control subjects.TC and TG were correlated with various thrombotic risk factors.The index of AIP was corresponding closely to BMI,DBP,GLU,TG,UA,non-HDLC,SBP,FⅦ and Hcy.AIP could accurately evaluate the risk of hyperlipidaemia patients,AIP was closely related to homocysteine,high uric acid hematic disease and high level of FⅦ,which formed the atherosclerosis risk factors.