AimTo investigate the association between the lipid-regulating effect of statins with the CETP-69G/A,-629C/A,-971G/A and -1337C/T polymorphisms.MethodsThe target DNA fragments of CETP gene were amplified and analyzed by PCR-RFLP technique in 207 dyslipidemia patients treated with statins. The relationship between each SNP and each blood-fat index was analyzed by SPSS statistic software.ResultsThe A allele was not found in the -69G/A polymorphism; After the treatment with simvastatin, the TC and LDLC decreasing extent were significantly different（P=0.025；P=0.000）between -629C/A genotypes, respectively.The -629AA individuals were 0.495 mmol/L（P=0.020）higher than CC individuals in TC decreasing extent. The LDLC decreasing extent were 0.577 mmol/L and 0.352 mmol/L （P=0.000, P=0.012） higher in -629AA and CA individuals than CC individuals; the -1337C/T polymorphisms was associated with the rising extent of HDLC level(F=3.064, P=0.044).The HDLC rising extent was gradually increased among -1337TT,TA and AA genotypes.There was no significant difference in the change of blood- fat level between the -971G/A genotypes after the treatment with simvastatin. ConclusionThe -629C/A and -1337C/T polymorphisms were associated with the lipid-regulating effect of statins.