AimTo investigate the prevalence of aortic valve sclerosis (AVS) in the high-risk group of cardio-cerebral vascular events, and to evaluate the clinical risk factors of AVS.Methods1058 individuals were enrolled in the cohort of the community of the Capital Steel Corporation in 2005.Participants were excluded if they had a history of any of the following diseases: rheumatic valve disease, bicuspid aortic valve malformation, prosthetic valve replacement, aortic valve stenosis.Risk factor status (including smoking， hypertension and diabetes etc) were adjudicated based on a review of data collected from hospitalizations and outpatient records.Total cholesterol and high density lipoprotein (HDL) cholesterol, triglycerides were measured from blood samples.Transthoracic echocardiography was performed to access the aortic valve sclerosis.And according to the results of the echocardiography, population was divided into two groups: AVS group and non-AVS group.Results1039 individuals were included in this study finally with mean age 62.47±8.99 years old.The prevalence of hypertension of 1039 individuals was 68.72% and of diabetes mellitus was 25.89%.AVS was present in 401 individuals (38.59%).The risk factors of AVS included age (OR=1.589,p<0.001), male(OR=2.263,p<0.001）, hypertension(OR=1.296,p=0.063）, diabetes mellitus (OR=1.794，p<0.001）.However after multivariate Logistic regression analysis, the independent risk factors of AVS included age (OR=1.507,p<0.001), male(OR=1.974,p=0.003), hypertension(OR=1.428,p=0.015), diabetes mellitus (OR=1.719,p<0.001）.ConclusionMultiple risk factors may involve in the progress of AVS.AVS and arteriosclerosis have some same risk factors which indicates that some factors for atherosclerosis may also play an important role in the prevalence of aortic valve sclerosis.