Aim To investigate the effect of Shensongyangxin capsule on QT dispersion and connexin43 expression in heart failure rats. Methods Heart failure rats models were built by constricting abdominal aorta,and were lavaged with Shensongyangxin capsule for 8 weeks.Ventricular electrophysiology were measured by inserting home-made electrode into subcutaneous,left ventricular morphostructure,myocardial fibrosis,and connexin43 distribution were respectively observed by HE staining,Masson staining,immunohistochemical staining. Results Heart failure rats QT dispresion were significantly longer(37.20±9.94 ms,P<0.05),cardiomyocytes were misaligned,myocardial fibrosis area were significantly increased(101217.30±33970.02 μm2,P<0.05),and connexin43 distribution were significantly decreased(55.93±11.61,P<0.05).Shensongyangxin capsule can shorten QT dispresion(25.50±8.21 ms) of heart failure rats,increase connexin43 distribution(69.09±16.59) and decrease myocardial fibrosis area(13580.64±8213.73 μm2) in myocardium of heart failure rats. Conclusion Shensongyangxin capsule can shorten QT dispresion of heart failure rats,increase connexin43 distribution and decrease myocardial fibrosis area in myocardium of heart failure rats.