Aim To evaluate the Changes among inflammatory factor diabetic retinopathy and plasma hyperhomocyssteinemia. Methods 150 type 2 diabetic patients were enrolled,and assigned to three groups: no diabetic retinopathy(NDR),background diabetic retinopathy(BDR) and proliferative diabetic retinopathy(PDR).All patients' inflammatory factors and plasma homocyssteine were measured.All patients'blood rheology analysis were measured. Results The plasma homocyssteine of BDR and PDR were significantly higher than NDR,the plasma homocyssteine of PDR was significantly higher than BDR.Whole blood viscosity and fibrinogen,plasma viscosity,ESR in group BDR and PDR were significantly higher than those in group NDR. Whole blood viscosity and fibrinogen,plasma viscosity,ESR in group PDR were significantly higher than those in group BDR. Conclusions Hyperhomocyssteinemia and hyperviscosity can cause diabetic retinopathy,hyperhomocyssteinemia is related with the severities' order of diabetic retinophthy.