AimTo study the correlation between coronary flow reserve(CFR), HbAlc and atherosclerosis of newly diagnosed type 2 diabetic mellitus.Methods80 cases with newly diagnosed type 2 diabetic mellitus were divided into diabetic plaque group and diabetic non-plaque group through ultrasonic examination of neck, iliac and femoral vascular.40 health people were chosen as control group.CFR and IMT were measured by transpleural color doppler ultrasound cardiogram, and the results were analyzed with Tei index.ResultCompared with control group, CFR of diabetic patients were obviously decreased, while plaque group had the lowest CFR (p<0.05); compared with non-plaque group, HbAlc of plaque group was obviously increased (p<0.05).IMT of diabetes patients was obviously bigger than control group, while in plaque group it was bigger than that in non-plaque group (p<0.05).The level of CFR was negatively correlated with low density lipoprotein, body mass, PWI, waist circumference, hip circumference, ln(FBG) of fasting blood glucose, IMT and Tei index (p<0.05).ConclusionCFR decreased with newly diagnosed type 2 diabetic patients and had good correlation with atherosclerosis.CFR testing is a predictor of newly diagnosed type 2 diabetic patients with atherosclerosis.