20-hydroxyeicosatetraenoic acid（20-HETE) is one of the products of cytochrome P-450 (CYP) catalyzing the ω-hydroxyl of arachidonic acid (AA).With the development of research,it has been discovered that 20-HETE played an important role in the process of organism blood pressure regulation,cerebral blood flow,myocardial contractility and renal function.Furthermore,20-HETE has a close relationship with the occurrence and development of diseases such as tumour,inflammatory function and so on.This article is to summarize the effects of 20-HETE in organism blood pressure and vascular function.