AimTo investigate the serum level of visfatin in the population with different obese type, and to analyse the relationship and clinical significance between visfatin and arterial stiffness.MethodsThe basic information was collected in a total of 1063 subjects who were enrolled by the physical examination center of the second people’s hospital of changzhou.Obesity measured by bioelectric impedance analysis, and divided the study population into four groups, based on percent of body fat and waist to hip ratio: normal, normal body weight but viscerally obese, excessive body weight but not viscerally obese, and excessive body weight and viscerally obese.Arterial stiffness was assessed by brachial-ankle PWV(baPWV).Fasting serum visfatin was tested by ELISA.ResultsComparison of the normal body weight group， the levels of serum visfatin and mean baPWV were significantly higher in the obese group, especially in the viscerally obese group (p<0.05).The serum levels of visfatin was positively correlated with baPWV, systolic BP, diastolic BP, hs-CRP（r=0.366, 0.217, 0.138, 0.253， respectively, p<0.05）.In a multivariate regression analysis, baPWV was independently determined by systolic BP（p<0.01）, age（p<0.01）, hs-CRP（p<0.01）, serum visfatin（p<0.01）, WHR（p<0.01）, diastolic BP(p=0.01), FPG（p=0.016）.Adjusted R² of the model was 0.765.ConclusionThe result suggest that the elevated level of visfatin is associated with systemic inflammation and artery stiffness in viscerally obese.The visfatin may act as a prediction factor in the cardiovascular disease.