AimTo explore comprehensive intervention of coronary heart disease under Hospital-Community Health Integrated Management Mode, and to evaluate the effects.Methods583 patients with coronary heart disease from Shengze Jiangsu were randomly recruited into two groups: intervention group (287 patients) and control group (296 patients).Patients in the intervention group received comprehensive intervention for 1.5 years from July of 2010 to January of 2011, including health education and behavior, psychological and drug intervention; while patients in the control group received conventional treatment and education on relative knowledge of coronary heart disease.ResultsAfter 1.5-year intervention, the coronary risk factors awareness rate and healthy-behavior formation rate had shown significant change (p<0.01).The index of blood pressure and weight were significantly decreased (p<0.01).The level of blood glucose and lipid profiles were significantly improved (p<0.05).The cardiovascular events significantly decreased (p<0.05).ConclusionEstablishing comprehensive intervention of coronary heart disease under Hospital-Community Health Integrated Management Mode is entirely feasible.It serves as important exemplifications and is worthy of popularizing.