Aim To discuss cardio-ankle vascular index （CAVI） and ankle-brachial index （ABI） in forecasting value of coronary heart disease （CHD）. Methods 256 patients were randomly selected in cardiology department of our hospital undergoing selective coronary angiography examination and treatment, among which 205 patients with CHD （stenosis≥50%） confirmed by coronary angiography were used as CHD group and divided into the corresponding sub-group according to the count of coronary artery disedse vessels, and the remaining 51 cases （stenosis＜50%） were used as control group （non-CHD group）. CAVI, ABI differences were compared in the two groups. Results Age, diabetes, hypertension, smoking, blood lipids were risk factors for CHD. With the severity of coronary stenosis, CAVI progressively increased, the difference between the two groups was statistically significant （P＜0.01）. ABI of non-CHD group and CHD group were in the normal range, but ABI of CHD group was lower than that of non-CHD group （P＜0.01）. ABI of multiple vessel disease group was lower than that of no-CHD group and single vessel disease group （P＜0.05）. CAVI（＋） predicted a higher sensitivity of CHD （66.4%）, poor specificity （32.7%） ABI reduction predicted a lower sensitivity of CHD （18.0%）, but high specificity （96.2%.） Conclusions CAVI（－） may be a significant independent predictor of non-CHD, CAVI （＋） is helpful for early detection of atherosclerosis, and lower ABI is an independent risk factor for CHD, which can be regarded as a reference index for the diagnosis of CHD.